Abstract
BackgroundPrevious studies showed that glutathione S-transferase Pi 1 (GSTP1) is a critical metabolic driver that is heightened specifically in triple negative breast cancer (TNBC) and drives breast cancer pathogenicity. This study focuses on investigating the relationship between the expression of the GSTP1 protein and TNBC metastasis and prognosis in China.ResultsChi-square and Fisher's exact tests showed that tumor size (P=0.023) and clinical stage (P=0.049) were significantly associated with GSTP1 expression. Patients with high GSTP1 expression exhibited an improved survival rate compared with patients with low GSTP1 expression, but the difference was not statistically significant (P=0.437). On multivariate analysis, clinical stage proved to be an independent prognostic factor for survival in breast cancer.Materials and methodsA total of 175 patients with histologically confirmed TNBC, who also underwent radical surgery between January 2008 and November 2011 at the Liaoning Cancer Hospital, were enrolled. Immunohistochemistry was used to detect GSTP1 expression in breast cancer tissue from 175 patients. The correlations between GSTP1 expression and other parameters were evaluated using the Chi-square and Fisher's exact tests. Univariate and multivariate Cox regression analyses were performed to assess independent prognostic factors for survival. Associations of GSTP1 expression with clinical stage and prognosis were analyzed using Kaplan–Meier survival curves.ConclusionsTumors with high GSTP1 protein expression were independently associated with low clinical stages in TNBC patients in China. The expression of the GSTP1 protein may be a novel prognosis marker for TNBC patients in China.
Highlights
Breast cancer (BC) is one among the most common malignancies in women, accounting for about 23% of all newly diagnosed cancers and 14% of cancer-related deaths [1]
Tumors with high glutathione S-transferase Pi 1 (GSTP1) protein expression were independently associated with low clinical stages in triple negative breast cancer (TNBC) patients in China
We found that the positive rate of GSTP1 expression was significantly higher in smaller tumors (P=0.023, Table 1) after calculating the association between GSTP1 protein expression and clinicopathological data of breast tumors
Summary
Breast cancer (BC) is one among the most common malignancies in women, accounting for about 23% of all newly diagnosed cancers and 14% of cancer-related deaths [1]. Patients with triple negative breast cancer (TNBC) account for about 15–20% of total BC cases, which have higher rates of metastasis and recurrence, and lower survival rates compared to other subtypes because these patients do not receive anti-receptor therapy. Louie S M. found that GST Pi 1 (GSTP1) was a new TNBC oncogene that governed the pathogenicity of cancer by regulating glycolysis, and energy and fat metabolism [7]. The goal of the present study was to investigate the relationship between the expression of the GSTP1 protein and the prognosis of patients with TNBC. Previous studies showed that glutathione S-transferase Pi 1 (GSTP1) is a critical metabolic driver that is heightened in triple negative breast cancer (TNBC) and drives breast cancer pathogenicity. This study focuses on investigating the relationship between the expression of the GSTP1 protein and TNBC metastasis and prognosis in China
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
