Prognostic significance of ferritin, D-dimer, lymphocyte / monocyte ratio and some biochemical markers in patients with SARS-CoV-2

Abstract

Objective: The disease caused by Covid-19 that progress with severe acute respiratory distress syndrome (SARS) and can result in death, spread all over the world emerging from China. It is important to know the cases that expected to show a fatal course beforehand due to the cases resulting in death. In this study we analyzed the changes observed in ferritin, D-dimer, lymphocyte and monocyte levels, which are easily measured in patients, and evaluated how these determinants can be used as prognostic factors of the disease.
 Materials and methods: One hundred patients who applied to Bezmialem Vakif University Hospital between April 2020 – May 2020, who were Covid-19 PCR positive, and had infiltration in their pulmonary computerised tomography scan, were included in the study. These patients were divided into two groups as normal service patients and intensive care unit patients. Ferritin, D-dimer, lymphocyte and monocyte levels, ALT, AST, LDH, and CRP levels were recorded at the time of diagnosis. Lymphocyte/monocyte ratio (LMR) was calculated.
 Results: Ferritin and D-dimer levels, ALT, AST, LDH, and CRP levels were found to be statistically and significantly higher in the mortality group compared to non-mortality (p<0.05). LMR, on the other hand, was found to be statistically and significantly lower in the mortality group (p<0.05).
 Conclusion: Ferritin, D-dimer levels and LMR can be determinant laboratory findings in the prognosis of the disease that are detected in the Covid-19 patients at the dime of diagnosis. More studies should be conducted to objectively evaluate disease-related prognostic factors.