Abstract
CD133 is one of the most important stem cell markers in solid cancers and Ki-67 is a marker that reflects cell proliferation. The relationships between the expression of CD133 and Ki-67 and prognosis in gastric carcinoma are unknown and need exploring. We examined 50 gastric cancer patients retrospectively in the Radiation Oncology Department of the Faculty of Medicine, Gazi University. CD133 and Ki-67 expression was examined using immunohistochemical staining. The survival rate in patients with CD133 positive expression was significantly worse than that in the patients with negative expression (p=0.04). Expression of CD133 had a positive correlation with that of Ki-67 (r=0.350; p=0.014). Multivariate analysis revealed that the expression of CD133 was an independent prognostic factor in gastric cancer (p=0.02). Conclusion, expression of CD133 may be a useful prognostic marker in gastric cancer.
Highlights
Gastric cancer (GC) is one of the most common and most aggressive human cancers
Expression of CD133 and Ki-67 in gastric adenocarcinoma When we looked at the ratio of CD133 expression, 3 samples had ratios more than 60%, 6 samples had ratios from 30% to 60% and 9 samples had ratios from 5% to 30%
These three groups were decided as CD133 positive expression (CD133+). 22 patients had not been painted, 9 patients had been painted lower than 5%
Summary
Gastric cancer (GC) is one of the most common and most aggressive human cancers. According to the World Health Organization, GC is the fifth most common malignancy worldwide, and with an extremely poor prognosis, is the third leading cause of cancer death worldwide (Ferlay et al, 2013). Despite having radical resection and postoperative adjuvant therapy, most of GC patients will die of recurrence and metastasis, with 5-year overall survival ratio only 20% for resectable patients in Turkey. Another problem with GC is time of the diagnosis because generally by the time the patient is clinically diagnosed, the GC has often grown beyond the limits of curative resection. 27% patients can be diagnosed with locally disease (Turkish Public Health Organization, 2009). Because of this fact, new early diagnostic tools and therapeutic techniques are needed
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