Abstract
Numerous individual studies evaluating the relationship between CD44V6 over-expression and prognostic impact in patients with osteosarcoma (OS) have yielded in conclusive results. This meta-analysis aimed to determine the value of cell adhesion molecule CD44V6 in prognosis of OS by conducting a systematic review and meta-analysis. A comprehensive search was conducted using PubMed (medline), Embase, ISI Web of Knowledge, Springer, the Cochrane Library, Scopus, BioMed Central, ScienceDirect, Wanfang, Weipu, and China National Knowledge Internet (CNKI) databases from inception through May 26, 2015. All available articles written in English or Chinese that investigated the expression of CD44V6 and the prognosis of OS were included. The quantity of the studies was evaluated according to the critical review checklist of the Dutch Cochrane Centre proposed by MOOSE. Finally, a total of eight studies with 486 OS patients were involved and the results indicated that the positive expression of CD44V6 predicts neoplasm metastasis (RR = 1.76, 95 % CI 1.38–2.25, p < 0.00001), and poor survival in OS with the pooled HR of 1.53 (95 % CI 1.25–1.88, p < 0.0001). No significant heterogeneity was observed among all studies. In conclusion, the present meta-analysis and systematic review strongly suggest that CD44V6 over-expression is associated with overall survival rate and metastasis in OS, and may be used as a prognostic biomarker to guide the clinical therapy for OS.Electronic supplementary materialThe online version of this article (doi:10.1186/s13018-015-0328-z) contains supplementary material, which is available to authorized users.
Highlights
Osteosarcoma (OS) is the most common malignancy originating from the bone that mainly afflicts the pediatric age group and young adults [1, 2]
Search strategy and selection criteria The PubMed, Embase, ISI Web of Knowledge, Springer, the Cochrane Library, Scopus, BioMed Central, ScienceDirect, Wanfang, Weipu, and China National Knowledge Internet (CNKI) databases were used to conduct a comprehensive search for studies that evaluated the accuracy of CD44 variant isoform V6 (CD44V6) for the metastasis and prognosis of OS
The present meta-analysis was conducted totally following the guidelines of preferred reporting items for meta-analysis of observational studies in epidemiology group (MOOSE) and MOOSE checklist for our study is shown in Additional file 1: Table S1
Summary
Osteosarcoma (OS) is the most common malignancy originating from the bone that mainly afflicts the pediatric age group and young adults [1, 2]. It is the second leading cause of cancer-related death in adolescents due to the fact that most of the patients involve in fatal metastasis. It is approximately 20–25 % of newly diagnosed patients have detectable lung-related metastasis [3, 4].
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