Abstract
BackgroundThis study aimed to explore the prognostic significance of tumor-associated macrophage (TAM) infiltration in colorectal cancer (CRC) patients.MethodsTissue microarray and immunohistochemistry were used to detect the infiltration of CD163+ TAMs in 209 CRC samples, and the Kaplan–Meier method was used for survival analysis. Cox proportional hazards analysis was used for univariate analysis and multivariate analysis of clinically relevant confounders.ResultsThe samples were divided into low-level (n = 105) and high-level infiltration groups (n = 104) by the median number of CD163+ TAMs detected. The overall survival (OS) and disease-free survival (DFS) of CRC patients in the low-level CD163+ TAM infiltration group were longer than those in the high-level CD163+ TAM infiltration group (P < 0.001). Infiltration of CD163+ TAMs in CRC tissues was a negative prognostic factor for CRC patients. Risks of death and disease recurrence for CRC patients in the low-level CD163+ TAM infiltration group were lower than those in the high-level CD163+ TAM infiltration group (HROS = 0.183, 95% CI 0.052–0.647, P = 0.008; HRDFS = 0.191, 95% CI 0.078–0.470, P = 0.000).ConclusionsThe infiltration of CD163+ TAMs in CRC tissue is an independent adverse factor for the prognosis of CRC patients. High-level infiltration of CD163+ TAMs is associated with shorter OS and DFS.
Highlights
This study aimed to explore the prognostic significance of tumor-associated macrophage (TAM) infiltration in colorectal cancer (CRC) patients
The results showed that the low-level TAM infiltration group (P < 0.001) had a prolonged overall survival (OS) (Fig. 2A), which was confirmed by the results of the univariate Cox regression analysis (Fig. 2C)
Cox regression analysis showed that TAM infiltration was an independent prognostic predictor of OS (Fig. 2C, D), and CRC patients with low-level TAM infiltration had a lower risk of death than patients with high-level TAM
Summary
This study aimed to explore the prognostic significance of tumor-associated macrophage (TAM) infiltration in colorectal cancer (CRC) patients. Numerous studies have shown that these immune cells interact with cancer cells in complex ways [1]. Studies have focused on the relationship between the clinical features, prognosis, and immune therapy of colorectal cancer (CRC) patients and immune cell infiltration of T lymphocytes [6, 7], Programmed deathligand 1(PD-L1) [8], and CD20+ B lymphocytes [9]. Activated M1 macrophages promote anti-tumor immune responses by regulating antigen presentation and secreting proinflammatory cytokines [13]. The purpose of this study was to evaluate the relationship between the infiltration of CD163+ TAMs and the clinical features and prognosis of CRC patients
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