Abstract
ABSTRACTObjective:To investigate the relationship between the pretreatment body mass index (BMI) and the clinical outcomes in patients with localized stage I - III renal cell carcinoma (RCC) surgically treated.Materials and Methods:From January 2000 to December 2012, 798 patients with stage I - III RCC were recruited from First Affiliated Hospital and Cancer Center of Sun Yat - Sen University. Patients were divided into two groups of BMI < 25 kg / m2 or BMI ≥ 25 kg / m2 according to the World Health Organization classifications for Asian populations. The differences in the long-term survival of these two BMI groups were analyzed.Results:The 5 - year failure - free survival rates for BMI < 25 kg / m2 and BMI ≥ 25 kg / m2 groups were 81.3% and 93.3%, respectively (P = 0.002), and the 5 - year overall survival rates were 82.5% and 93.8%, respectively (P = 0.003). BMI was a favored prognostic factor of overall survival and failure - free survival in a Cox regression model.Conclusions:Pretreatment body mass index was an independent prognostic factor for Chinese patients surgically treated, localized stage I - III RCC.
Highlights
Renal cell carcinoma (RCC) is one of the most common urologic malignancies, and its incidence has steadily increased in recent decades
Several epidemiological studies have suggested that obesity is a risk factor for the development of RCC [1, 11, 14]
A more contemporary retrospective review of 400 patients undergoing nephrectomy for RCC by Kamat et al appears to confirm a more favorable prognosis and disease specific survival in overweight and obese patients when compared to normal weight patients [20]
Summary
Renal cell carcinoma (RCC) is one of the most common urologic malignancies, and its incidence has steadily increased in recent decades. Several risk factors for developing of RCC have been reported, including smoking, hypertension and obesity [1]. Stratification of the patients with RCC into categories with different risk of local recurrence, progression and survival would improve the standard of preoperative patient’s counseling and treatment planning. Clinical, histological and molecular variables can predict the probabilities of recurrence, progression, and both overall and cancer - specific survival of the patients with RCC [2]. Obesity seems to increase the risk of developing RCC [1]
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