Prognostic significance of biomarkers in the early diagnosis of nephropathy in diabetes mellitius II type

Abstract

Clinical and laboratory markers evaluating the development of nephropathy were studied in 62 patients in the compensation period of type II diabetes. A comparative analysis of the relationship between the results of laboratory biomarkers and the duration of the disease was carried out. 62 patients (including 30 men, 32 women) in the compensation stage of type II diabetes were involved in the research work. Their average age is 48.4 ± 1.2. Systolic and diastolic blood pressures were 154.1 ± 1.8 and 99.8 ± 1.5 mmHg, respectively. above average blood sugar, glycosylated hemoglobin values were 8.4 ± 1.6 mmol/l and 8.0 ± 1.5%, respectively. All patients had an average GFR of 71.8 mL/min or more per 1 minute per 1.73 m 2 body surface area. The results of the analysis showed that in the early years of diabetes, patients had a clear nephrinuria, without the appearance of clinical symptoms of nephropathy. Currently, MAU is detected in the 3-4th year of the disease. Hyperfiltration was observed in 30.6% of patients, and 24.1% of these patients had no renal functional reserve at all during the 4-5 years of the disease.