Abstract
Many studies have reported β-catenin involvement in the development of esophageal carcinoma (EC), but its prognostic significance for EC patients remains controversial. Therefore, we conducted this meta-analysis to explore the issue in detail. After searching PubMed, EMBASE, Web of Science, and Chinese Biomedical Literature Database, we included a total of ten relevant studies. We pooled the overall survival (OS) data using RevMan 5.2 software. The results showed that aberrant expression of β-catenin was associated with a significant increase of mortality risk (hazard ratio 1.71, 95%CI 1.46-2.01; p<0.00001). Subgroup analyses further suggested that aberrant expression of β-catenin resulted in poor OS of EC patients regardless of histological type of EC, study location or criteria for aberrant expression of β-catenin, and the sensitivity analyses revealed that the result was robust. The meta-analysis revealed that aberrant expression of β-catenin could be a predicative factor of poor prognosis for EC patients.
Highlights
Esophageal carcinoma (EC) is one of the most common malignant tumors worldwide (Jemal et al, 2009), and has even become a global health problem
The results showed that aberrant expression of β-catenin was associated with a significant increase of mortality risk
Subgroup analyses further suggested that aberrant expression of β-catenin resulted in poor overall survival (OS) of esophageal carcinoma (EC) patients regardless of histological type of EC, study location or criteria for aberrant expression of β-catenin, and the sensitivity analyses revealed that the result was robust
Summary
Esophageal carcinoma (EC) is one of the most common malignant tumors worldwide (Jemal et al, 2009), and has even become a global health problem. Many studies reported that β-catenin was involved in the development of EC, its prognostic significance for EC patients remains controversial (Krishnadath et al, 1997; Shiozaki et al, 2000; Hsu et al, 2008; Lin et al, 2008; Li et al, 2009; Nozoe et al, 2009; Situ et al, 2010; Chen et al, 2011; Wang et al, 2011; Lv et al, 2012). We conducted this meta-analysis to determine whether β-catenin could be a prognosis factor in EC
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