Abstract
Artemin (ARTN) has been implicated in the development and progression of several human malignancies. However, the clinical and prognostic significance of ARTN and its receptors has not yet been investigated in human laryngeal squamous cell carcinoma (LSCC). Therefore, in the present study, the protein expression of ARTN and its receptor, namely GFRα1, was determined in 76 LSCC and 26 laryngeal polyp tissue samples using immunohistochemistry. Furthermore, the clinicopathological and prognostic significance of ARTN and GFRα1 expression was analyzed in patients with LSCC. The results revealed that the expression of ARTN and GFRα1 was significantly increased in LSCC compared with polyp tissue samples. Furthermore, the expression of ARTN and GFRα1 was positively associated with pTNM stage in LSCC. Kaplan-Meier survival analyses revealed a strong association between the expression of ARTN or GFRα1 and the survival of patients with LSCC. Correlation analysis demonstrated that the expression of ARTN was significantly correlated with the expression GFRα1. In conclusion, the results demonstrated that ARTN and GFRα1 may be useful predictors of disease progression and outcome in patients with LSCC.
Highlights
Laryngeal squamous cell carcinoma (LSCC) is one of the most common malignancies in the head and neck region, which leads to 350,000 mortalities worldwide each year [1,2]
Expression of ARTN and GFRα1 protein is upregulated in LSCC tissue samples
No significant association was observed between the expression of ARTN and GFRα1 and any other clinicopathological characteristics, including tumor site, tumor differentiation and tumor lymph node metastasis
Summary
Laryngeal squamous cell carcinoma (LSCC) is one of the most common malignancies in the head and neck region, which leads to 350,000 mortalities worldwide each year [1,2]. High expression levels of ARTN have been observed be significantly associated with high tumor grade and myometrial invasiveness in clinical tissue specimens, and forced expression of ARTN has been demonstrated to increase tumor cell growth and invasiveness in vivo and in vitro [11]. Co-expression of ARTN with its receptors has been found to produce synergistic increases in the odds ratio for survival in patients with breast cancer [15]. These results suggest that ARTN with its receptors may have an important role in human solid tumors. To the best of our knowledge, the clinical impact and prognostic significance of ARTN or its receptor expression in human LSCC has not yet been investigated
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