Abstract
The elevated growth hormone (GH) and insuline-like growth-factor 1 (IGF-I) levels lead to a wide range of cardiovascular, respiratory, endocrine, and metabolic morbidities [ [1] Melmed S. Acromegaly. N Engl J Med. 1990; 322: 966-977 Crossref PubMed Scopus (509) Google Scholar ]. Direct effects of GH and IGF-1 on vasculature over traditional risk factors were suggested. In recent studies, early alterations in aortic distensibility have been demonstrated in acromegalics [ 2 Smith J.C. Lane H. Davies N. et al. The effects of depot long-acting somatostatin analog on central aortic pressure and arterial stiffness in acromegaly. J Clin Endocrinol Metab. 2003; 88: 2556-2561 Crossref PubMed Scopus (36) Google Scholar , 3 Nemes A. Gavallér H. Csajbók E. Julesz J. Forster T. Csanády M. Aortic stiffness is increased in acromegaly—a transthoracic echocardiographic study. Int J Cardiol. 2008; 124: 121-123 Abstract Full Text Full Text PDF PubMed Scopus (18) Google Scholar , 4 Nemes A. Gavallér H. Csajbók E. Lengyel C. Forster T. Csanády M. Does diabetes mellitus facilitate aortic stiffening in acromegaly?. Diabetes Res Clin Pract. 2007; 78: e7-e8 Abstract Full Text Full Text PDF PubMed Scopus (5) Google Scholar ]. However, prognostic information on vascular distensibility alterations in this patient population has never been investigated. Therefore the present study was designed to assess whether echocardiography-derived ascending aortic stiffness index (ASI) in acromegaly patients has a prognostic significance to assess event-free survival during a long-term follow-up.
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