Abstract
Annexin A1 is a 37-kDa calcium- and phospholipid-binding protein of the annexin superfamily considered to play an important role in tumorigenesis. However, associations with clinicopathological features in pancreatic ductal adenocarcinoma (PDAC) cases have yet to be fully defined. We therefore investigated the prognostic value of annexin A1 protein as a PDAC biomarker in 83 tumor and matched non-cancerous tissues or normal pancreas tissues. Expression was analyzed using real-time RT-PCR, Western blotting and immunohistochemistry. In non-tumor tissue, myoepithelial cells showed no or weak expression of annexin A1 while expression was strong and sometimes even located in the nuclei of endothelial cells in tumor tissue. High expression was significantly associated with advanced stage (P <0.05) and a worse overall survival (P <0.05). These results provide new insights to better understand the role of annexin A1 in PDAC survival, and might be relevant to prediction of prognosis and development of more effective therapeutic strategies aimed at improving survival.
Highlights
Pancreatic ductal adenocarcinoma (PDAC), which represents 90% of pancreatic cancers, is among the worst malignancies whose average 5-year survival is a dismal 4% (Taghavi et al, 2011)
High expression was significantly associated with advanced stage (P
It has been reported that annexin A1 is up-regulated in hepatocellular carcinoma
Summary
Pancreatic ductal adenocarcinoma (PDAC), which represents 90% of pancreatic cancers, is among the worst malignancies whose average 5-year survival is a dismal 4% (Taghavi et al, 2011). Prognostic biomarkers of PDAC are relatively lacked which results in a relatively unavailable monitoring of the progressing (Winter et al, 2012). More and more studies have made effects to investigate efficient biomarkers for the early detection, diagnosis, and monitoring of cancers (Bhat et al, 2012). As a kind of multifunctional calcium-dependent phospholipidbinding protein found in almost all organisms across all kingdoms (Hayes & Moss., 2004), annexins have received more and more attention as novel biomarkers of cancer. Recent interest in the biological activity of this intriguing molecule has unraveled important functional attributes of annexin A1 in the process of carcinogenesis (Fatimathas & Moss., 2010). Studies have proved that the expression of annexin A1 was in a tissue-specific and tumor-specific manner, which means the expression of annexin A1 is significantly different among various types of tissues, tumor tissues and that in normal counterparts, and is closely related to the malignant growth of tumor cell
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