Prognostic Role of Squamous Cell Carcinoma Antigen in Cervical Cancer: A Meta-analysis.

Zhenhua Liu,Hongtai Shi

doi:10.1155/2019/6710352

Zhenhua Liu, Hongtai Shi

Open Access

https://doi.org/10.1155/2019/6710352

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Journal: Disease markers	Publication Date: Jun 2, 2019
Citations: 30	License type: CC BY 4.0

Affiliation: Yancheng Third People's Hospital

Abstract

Objective To systematically evaluate the significance of squamous cell carcinoma antigen (SCC-Ag) in the prognosis of cervical cancer. Methods Literature from Pubmed, Embase, and Cochrane Library was retrieved to collect all English literature on the correlation between SCC-Ag and cervical cancer prognosis, and the quality of literature collected was assessed based on evaluation criteria. The heterogeneity, sensitivity, and specificity were detected using the StataSE12.0 software, and the correlation between SCC-Ag and cervical cancer prognosis as the effect variables was assessed using the hazard ratio (HR) and 95% confidence interval (CI). Moreover, the forest map and funnel plot were drawn. Results A total of 17 articles meeting the inclusion criteria were selected. The high expression of SCC-Ag was significantly correlated with the poor prognosis of cervical cancer (HR = 2.22, 95% CI = 1.38 − 3.57, P = 0.002). The disease-free survival (DFS) was higher in low SCC-Ag expression patients than in high SCC-Ag expression patients (HR = 2.17, 95% CI = 1.84 − 2.57, P < 0.001). The progression-free survival (PFS) was inferior in patients with a high SCC-Ag expression (HR = 2.70, 95% CI = 1.11 − 6.53, P = 0.028). Conclusion SCC-Ag is an important prognostic factor for cervical cancer, and its high expression is significantly correlated with a poor prognosis of the disease.

Highlights

Cervical cancer is the third most common cancer in females around the world and the fourth leading cause of cancer death [1]
Publication inclusion criteria are as follows: (1) studies based on cervical cancer patients; (2) published epidemiological studies, such as case-control studies and line-up studies; (3) studies evaluating the diagnostic value of tumour markers for cervical cancer; (4) positive values or hazard ratio (HR) and 95% confidence interval (CI) of the case group and the control group were clearly reported, or the corresponding four-table data were provided; (5) research methods and scope were similar, and detection methods were the same; (6) the relationship between Squamous cell carcinoma antigen (SCC-Ag) expression and prognosis of cervical cancer was reported; and (7) the data and information were complete
A total of 387 publications related to SCC-Ag expression and the prognosis of cervical cancer were retrieved

Summary

Introduction

Cervical cancer is the third most common cancer in females around the world and the fourth leading cause of cancer death [1]. The early symptoms of cervical cancer are not obvious, so patients are often diagnosed in the advanced stages, which directly affects the quality of life and prognosis of patients. Squamous cell carcinoma is the most common. Squamous cell carcinoma antigen (SCC-Ag) is an early tumour marker for diagnosing cervical cancer and monitoring responses to treatment in the event of relapse. In the diagnosis and detecting recurrence of cervical cancer, SCC-Ag has been clearly validated. The clinical stage, depth of invasion, tumour size, and lymph node metastasis of SCC have enormous significance in the prognosis [4]. By continuous monitoring of SCC-Ag, early SCC recurrence may be detected and appropriate remedial treatment can be prescribed for early intervention, thereby improving the quality of life and prolonging survival [5].

Methods

Results

Conclusion