Prognostic Role of PTEN Gene Expression and Length of Survival of Breast Cancer Patients in the North East of Iran.

Rahim Golmohammadi,Akbar Pejhan,Mohammad Hassan Rakhshani,Ali Reza Moslem

doi:10.7314/apjcp.2016.17.s3.305

Rahim Golmohammadi, Akbar Pejhan + Show 2 more

Open Access

https://doi.org/10.7314/apjcp.2016.17.s3.305

Copy DOI

Abstract

PTEN protein is an important tumour suppressor factor detectable by immunohistochemistry. The goal of the present study was to investigate the prognostic role of PTEN gene expression focusing on length of survival in breast cancer patients. This descriptive-analytical study was conducted on 100 breast cancer cases referred to Sabzevar hospitals in the north east of Iran between 2010 and 2011, followed up to 2015. The PTEN gene expression of tumour tissue samples was determined using specific monoclonal antibodies. The data were analyzed using Chi-square test and Fisher's exact test. Patient length of survival was analyzed after 4 years of follow-up using the Cox regression model. The PTEN gene was expressed in 70 of 100 samples, while being found at a high level in all noncancerous samples. There was an inverse significant relationship between expression of PTEN and tumour stage and grade (p<0.001). In addition, expression of PTEN in invasive ductal tumours was less than in non-invasive tumours. There was also an inverse significant relationship between the likelihood of death and PTEN gene expression (p<0.01). These findings indicate that lack of PTEN gene expression can be sign for a poor prognosis in breast cancer.

Highlights

Breast cancer is considered as one of the most important malignancies in women in the U.S (Cianfrocca and Goldstein, 2004)
The present study indicated that there is a significant relationship between decreased PTEN gene expression and tumour stage
Previous studies showed that the risk of metastasis of cancerous cells to other tissues is greater in breast cancer patients without PTEN gene expression (Tsutsui et al, 2005; Wikman et al, 2012)

Summary

Introduction

Breast cancer is considered as one of the most important malignancies in women in the U.S (Cianfrocca and Goldstein, 2004). One in 8-12 individuals is diagnosed with breast cancer. Breast cancer is the second leading cause of mortality in women (Dunning et al, 1999). In Asia, the prevalence of breast cancer has been increasing during the recent years (Lam et al, 2005). Non-invasive carcinomas account for about 15-30% of all breast cancer cases and include ductal carcinoma in situ (DCIS) and lobular carcinoma in situ (LCIS). Invasive carcinomas comprise 70-85% of breast cancer cases and include invasive ductal carcinoma (IDC) as well as invasive lobular carcinoma (ILC) (Kumar et al, 2007)

Objectives

Methods

Results

Conclusion