Abstract

BackgroundThe relationship between cancer and coagulation has been intensively studied in recent years; however, the effects of coagulation factors on oral squamous cell carcinoma (OSCC) have rarely been reported. This study aimed to investigate the relationship between preoperative D-dimer (DD), fibrinogen (FIB), platelets (PLT) and OSCC, as well as the prognostic value of DD, FIB and PLT in OSCC.MethodsWe retrospectively investigated a total of 202 patients with OSCC treated at Guanghua Hospital of Stomatology, Sun Yat-sen University. Baseline demographic and clinicopathological information as well as both preoperative and postoperative DD, FIB and PLT results were collected from each patient, and patients with primary OSCC were followed up for disease progression, death or the end of the study. The correlations between preoperative DD, FIB, PLT and other clinical features, as well as the therapeutic effect and PFS were analysed statistically, and postoperative DD and surgical parameters were also analysed.ResultsPreoperative DD was significantly correlated with T stage, N stage, clinical stage and relapse of OSCC (P = 0.000, 0.001, 0.000 and 0.000, respectively). Univariate Cox regression analyses showed that high preoperative DD predicted poor prognosis in patients with OSCC (HR = 2.1, P = 0.033), while FIB and PLT showed no prognostic values. Postoperative DD was significantly correlated with preoperative DD and surgical type but not the duration of surgery (P = 0.005, 0.001 and 0.244, respectively).ConclusionIn this study, we suggested that high preoperative DD level may serve as an indicator for synchronous neck dissection in patients with T1, 2 OSCC, and the elevated DD level might be the marker of disease progression in patient follow up.

Highlights

  • The relationship between cancer and coagulation has been intensively studied in recent years; the effects of coagulation factors on oral squamous cell carcinoma (OSCC) have rarely been reported

  • Preoperative DD was significantly correlated with T stage, N stage, clinical stage and relapse of OSCC

  • In this study, we suggested that high preoperative DD level may serve as an indicator for synchronous neck dissection in patients with T1, 2 OSCC, and the elevated DD level might be the marker of disease progression in patient follow up

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Summary

Introduction

The relationship between cancer and coagulation has been intensively studied in recent years; the effects of coagulation factors on oral squamous cell carcinoma (OSCC) have rarely been reported. Fibrinogen (FIB) and platelets (PLT) can partly reveal the coagulation state of the patient. Previous studies have reported that pre-treatment plasma DD, FIB and PLT levels can predict prognosis in several types of malignancies, including ovarian [3], breast [4, 5], lung [6, 7], colorectal [8], gastric [9], and pancreatic cancers [10]. To the best of our knowledge, this is the first study to address the prognostic significance of perioperative DD, FIB and PLT levels and their relationship with clinicopathologic parameters in patients with OSCC

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