Abstract
9563 Background: neuroendocrine (NE) differentiation in prostate cancer (PC) is more frequently expressed in hormone refractory patients than in those with hormone naive disease. Chromogranin A (CgA) is the most employed marker to detect NE features. Methods: plasma CgA (ELISA kit, DAKO, Glostrup-Denmark, reference range in PC patients 2–20 U/L) was evaluated at baseline conditions in 108 consecutive patients with hormone refractory PC. Results: patients characteristics were as follows: median age 74 yrs (range 58–86), median ECOG performance status 1 (range 0–3). 105 patients (97.2%) had metastatic bone disease, 91 patients (84,2%) had elevated PSA values (median 97.0 ng/ml, range 0.1–3393.0). Median CgA values was 17.3 U/L (range 3.0–394.0), supranormal CgA values were recorded in 45 patients (43.3%). Baseline elevated plasma CgA correlated with a shorter survival perspect: 11.13 months (range: 3.5–18.7) vs 22.37 months (range: 13.7–31.0) (p=0.02). In a multivariate analysis, plasma CgA provided indepen...
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
