Abstract
Background: Published data have shown that microRNAs (miRNAs) could play a potential role as diagnostic and prognostic indicators in cancers. Data for the predictive value of miRNA let-7, miR-21, and miR-205 are inconclusive. The aim of the present analysis was therefore to evaluate the expression and the prognostic role of the above mentioned miRNAs in early-stage (T1N0) NSCLC patients. Methods: Quantification of let-7g, miR-21, and miR-205 expression was carried out into 105 early-stage NSCLC by quantitative Real Time-PCR (qRT-PCR). Results: a significant association between the low miR-205 expression and ADC histotype (p 0.0001) compared to SCC was found; moreover, survival analysis showed thattumors with a high miR-205 expression had a significantly shorter mean PFS and OS compared to the patients with a low expression of this miRNA (p = 0.02 and p = 0.03, respectively). No other statistically significant correlations were observed between the analysed miRNAs and the main clinico-pathological characteristics of the NSCLC patients. Conclusion: The results indicated that miR-205 could represent a useful marker in the prognostic management of the early-stage (T1N0) NSCLC patients.
Highlights
MicroRNAs are short, non-coding RNAs of approximately 19 - 24 nucleotides in length, emerged forHow to cite this paper: Boldrini, L., et al (2014) Prognostic Role of miR-205 in Early-Stage (T1N0) Non-Small Cell Lung Cancer
Altered miRNA expression has been implicated in several carcinomas, including non-small cell lung cancer (NSCLC); aberrant expression of miRNAs is significantly related to tumor stage, suggesting that they could be potential markers for cancer prognosis [5] [6]
This study was conducted in 105 patients with early-stage NSCLC (T1N0), including 57 adenocarcinomas
Summary
How to cite this paper: Boldrini, L., et al (2014) Prognostic Role of miR-205 in Early-Stage (T1N0) Non-Small Cell Lung Cancer. Since their initial discovery in 1993 [1], several published data found that some of these miRNAs act as oncogenes, whereas others exhibit tumor suppressor properties [2]-[4]. Published data have shown that microRNAs (miRNAs) could play a potential role as diagnostic and prognostic indicators in cancers. Conclusion: The results indicated that miR-205 could represent a useful marker in the prognostic management of the early-stage (T1N0) NSCLC patients
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