Abstract
BackgroundRecent studies show that microRNA-145 (miR-145) might be an attractive tumor biomarker of considerable prognostic value. To clarify the preliminary predictive value of miR-145 for prognosis in various malignant neoplasms, we conducted a meta-analysis of 18 relevant studies.MethodsEligible studies were identified by searching the online databases PubMed, EMBASE, and Web of Science up to March 2014. Pooled hazard ratios (HRs) with 95% confidence intervals (CIs) for patient survival and disease progress were calculated to investigate the association with miR-145 expression.ResultsIn total, 18 eligible studies were included in this meta-analysis. Our results showed that upregulated miR-145 significantly predicted a favorable overall survival (OS) (HR = 0.47, 95% CI 0.31 to 0.72), but failed to show a significant relation with disease prognosis. In stratified analyses, high miR-145 expression predicted favorable OS in both Whites and Asians but the intensity of the association in Whites (HR = 0.67, 95% CI 0.47 to 0.95) was not as strong as in Asians (HR = 0.35, 95% CI 0.19 to 0.64). High miR-145 expression also predicted better progression-free survival (PFS) in Asians (HR = 0.43, 95% CI 0.21 to 0.89), but not in Whites. In addition, a significantly favorable OS associated with upregulated miR-145 expression was observed in both squamous cell (SCC) (HR = 0.34, 95% CI 0.13 to 0.93) and glioblastoma (HR = 0.72, 95% CI 0.52 to 0.99).ConclusionsOur findings indicate that high miR-145 expression is better at predicting patient survival rather than disease progression for malignant tumors, especially for SCC and glioblastoma in Asians. Considering the insufficient evidence, further investigations and more studies are needed.
Highlights
Recent studies show that microRNA-145 might be an attractive tumor biomarker of considerable prognostic value
In hepatocellular carcinoma (HCC), miR-145 was found to target a number of genes along the signaling pathway of insulin-like growth factor (IGF), including IGF-1 receptor, insulin receptor substrate-1 (IRS-1), and IRS-2, all of which are directly downregulated by miR-145 [8]
The malignant neoplasms studied consisted of glioma, non-small cell lung cancer (NSCLC), head and neck cancer (HNC), prostate cancer (PCa), osteosarcoma, HCC, and colorectal, esophageal, cervical, breast, and ovarian cancers
Summary
Recent studies show that microRNA-145 (miR-145) might be an attractive tumor biomarker of considerable prognostic value. To clarify the preliminary predictive value of miR-145 for prognosis in various malignant neoplasms, we conducted a meta-analysis of 18 relevant studies. Emerging studies have demonstrated that deregulated expression of microRNAs (miRNAs) correlates with cancer prognosis because of the distinct expression profiles of these miRNAs in cancerous tissues compared with normal tissues [1,2,3]. A large number of studies have put particular emphasis on the upregulated expression of various miRNAs that are usually associated with poor prognosis in malignant neoplasms, known as ‘hazardous miRNAs’ [1,2,3,4,5]. Some recent studies have transferred attention to the downregulated expression of several miRNAs that are.
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