Prognostic role of echocardiography to predict cardiovascular involvement in systemic sclerosis

Abstract

Abstract Funding Acknowledgements Type of funding sources: None. Purpose. Cardiovascular involvement in systemic sclerosis (SSc) is frequent, often subtle, and is associated with poor prognosis. Our aim was to compare echocardiographic data of SSc patients to controls, and to assess parameters able to predict the development of cardiovascular involvement. Methods. We enrolled 756 SSc patients (Group 1) without a previous diagnosis of cardiac involvement nor pulmonary arterial hypertension (PAH), and 614 healthy controls (Group 2) matched for age (Group 1 54.9 ± 14.6 years vs Group 2 54.4 ± 12.1, p = 0.6), sex (7.3% vs 7.2%, p = 0.8), and prevalence of hypertension (17.8% vs 19.8%, p = 0.2). All subjects underwent a comprehensive transthoracic 2D and Doppler echocardiography, including tissue Doppler imaging analysis (TDI). Five hundred and two SSc patients were followed-up and the development of PAH, left-sided heart failure (LHF), right-sided heart failure (RHF), and need of implantable cardioverter defibrillator (ICD) were considered as events. Results. Compared to controls, SSc patients showed worse left and right ventricular systolic and diastolic function, hemodynamics and right ventricle-arterial coupling (tricuspid annulus plane systolic excursion over systolic pulmonary artery pressure, TAPSE/sPAP) (Table). After a median follow-up with of 35 moths, 45 composite events (PAH, LVH, RHF and ICD) occurred. In a multivariate model, only ejectioin fraction (EF) and TAPSE/sPAP had independent prognostic value (Table). Conclusions. SSc patients without overt cardiovascular involvement and no PAH display subtle impairments in biventricular systo-diastolic function and right ventricle-arterial coupling. Left ventricular EF and TAPSE/sPAP can predict further cardiovascular events. Descriptive analysis and Cox regression Descriptive Univariate Multivariate VARIABLE Group 1 (Ssc) n = 756 Group 2 (controls) n = 614 p HR (95 % CI) p HR (95% CI) p Ejection fraction (%) 63 ± 5.7 63.7 ± 5.9 0.038 0.94 (0.88 - 0.99) 0.024 0.91 (0.85 - 0.98) 0.017 E/A 1.0 ± 0.46 1.2 ± 0.51 <0.0001 1.41 (0.77 - 2.58) 0.26 e’ mean (mm) 10.7 ± 3 11.2 ± 3.4 0.034 0.87 (0.76 - 0.99) 0.038 1.0 (0.87 - 1.17) 0.902 Left atrial volume index (mL/m2) 26.5 ± 7.7 21.3 ± 6.7 <0.0001 1.03 (0.98 - 1.1) 0.24 TAPSE (mm) 22.1± 23.3± <0.0001 0.89 (0.81 - 0.97) 0.012 sPAP (mmHg) 24.7± 22.3± <0.0001 1.07 (1.04 - 1.1) < 0.0001 TAPSE/sPAP (mm/mmHg) 0.98 ± 0.96 1.1 ± 0.39 <0.0001 0.036 (0.009 - 0.141) < 0.0001 0.03 (0.004 - 0.19) < 0.0001 Pericardial effusion 57 (7.5%) 0 (0%) <0.0001 1.10 (0.38 - 3.15 ) 0.85