Abstract
BackgroundThe morbidity and mortality of cancer increase remarkably every year. It's a heavy burden for family and society. The detection of prognostic biomarkers can help to improve the theraputic effect and prolong the lifetime of patients. microRNAs have an influential role in cancer prognosis. The results of articles discussing the relationship between microRNA polymorphisms and cancer prognosis are inconsistent.MethodsWe conduct a meta-analysis of 19 publications concerning the association of four common polymorphisms, mir-146a rs2910164, mir-149 rs2292832, mir-196a2 rs11614913 and mir-499 rs3746444, with cancer prognosis. Pooled Hazard Ratios with 95% Confidence Intervals for the relationship between four genetic polymorphisms and Overall Survival, Recurrence-free Survival, Disease-free survival, recurrence are calculated. Subgroup analysis by population and type of tumor are conducted.ResultsGG genotype of mir-146a may be the protective factor for overall survival, especially in Caucasian population. C-containing genotypes of mir-196a2 act as a risk role for overall survival. The same result exists in Asian population, in Non-Small Cell Lung Cancer and digestive cancer. The patients with C allele of mir-149 have a better overall survival, especially in Non-Small Cell Lung Cancer. No significant results are obtained for mir-499 polymorphisms.ConclusionsGenetic polymorphisms in mir-146a, mir-196a2 and mir-149 may be associated with overall survival. This effect varies with different types of cancer. Genetic polymorphism in mir-499 may have nothing to do with cancer prognosis.
Highlights
Cancer is a primary cause of morbidity and mortality in the vast marjority of regions in the world
A significant result existing in dominant model indicats the protective role of homologous frequent genotype in overall survival (HR = 0.74, 95%CI 0.61– 0.94, P = 0.004, Table 1)
The association between mir-146a polymorphisms and overall survival was observed in American population in dominant model (P = 0.004, Table 2)
Summary
Cancer is a primary cause of morbidity and mortality in the vast marjority of regions in the world. Cancer itself and medical treatment for cancer have been a heavy burden for both family and society. The detection of biomarkers will help to diagnose underlying patients at an early period and the identification of targeted genetic sites can promote the theraputic effect and prolong the lifetime of patients. The morbidity and mortality of cancer increase remarkably every year. It’s a heavy burden for family and society. The detection of prognostic biomarkers can help to improve the theraputic effect and prolong the lifetime of patients. MicroRNAs have an influential role in cancer prognosis. The results of articles discussing the relationship between microRNA polymorphisms and cancer prognosis are inconsistent
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