Abstract
To explore the association of the biochemical markers after birth with BPD-PAH, factors independently predicting BPD-PAH risk were identified by multivariate logistic regression. Cut off values were determined by plotting receiver-operator curve (ROC), for the sake of dichotomizing continuous variables that showed independent relation with BPD-PAH risk. The results show that uric acid (UC) and blood urea nitrogen (BUN) contents markedly increased among infants experiencing BPD-PAH in comparison with those without BPD-PAH (11.6 vs. 9.7 mmol/L, P = 0.006 and 482.0 vs. 249.0 μmol/L, P < 0.001, separately). As shown by multivariate logistic regression, serum BUN levels (OR = 1.143) and uric acid levels (OR = 1.034) were important risk factors for BPD-PAH. Through a lot of experiments, the effectiveness and the advanced nature of the framework proposed in this paper are proved effectively. The framework proposed in this paper can provide some reference and thinking for follow-up research.
Highlights
Pulmonary arterial hypertension _(PAH) related to bronchopulmonary dysplasia (BPD-PAH) in infants is fatal, which has affected more and more premature infants
Some factors were verified to be related to BPD-PAH occurrence, such as LBW, PDA, and SGA [5, 6]
The growth of pulmonary blood vessels depends on endothelial cells as well as diverse cytokines and growth factors, with vascular endothelial growth factors (VEGFs) being the critical ones [7,8,9]
Summary
Pulmonary arterial hypertension _(PAH) related to bronchopulmonary dysplasia (BPD-PAH) in infants is fatal, which has affected more and more premature infants. It is necessary to identify biomarkers as the first-line approaches for screening. Many PAH-related biomarkers are identified, like troponin-T and NT-pro brain natriuretic peptide whose measurable contents predict the increase PAH mortality [1]. The elevated uric acid (UC) levels can be detected in PAH, the study population has been mostly limited to adults and children. It is not yet clear whether the elevated levels are associated with BPD-PAH in extreme infants. This work focused on investigating the association of first biochemical markers after birth with BPD-PAH occurrence among the extremely premature infant (EPI) population
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