Abstract
Purpose. To assess the prognostic role of 14F7 Mab immunoreactivity, against N-Glycolyl GM3 ganglioside, in patients with colon cancer (CC) and to evaluate the relationship between its expression and clinicopathological features. Methods. Paraffin-embedded specimens were retrospectively collected from 50 patients with CC operated between 2004 and 2008. 14F7 Mab staining was determined by immunohistochemistry technique and its relation with survival and clinicopathologic features was evaluated. Results. The reactivity of 14F7 Mab was detected in all cases. Most cases had high level of immunostaining (70%) that showed statistical correlation with TNM stage (P = 0.025). In univariate survival analysis, level of 14F7 Mab immunoreactivity (P = 0.0078), TNM Stage (P = 0.0007) and lymphovascular invasion (0.027) were significant prognostic factors for overall survival. Among these variables, level of 14F7 Mab immunoreactivity (HR = 0.268; 95% CI 0.078–0.920; P = 0.036) and TNM stage (HR = 0.249; 95% CI 0.066–0.932; P = 0.039) were independent prognostic factors on multivariate analysis. Conclusions. This study is the first approach on the prognostic significance of 14F7 Mab immunoreactivity in patients with colon adenocarcinoma and this assessment might be used in the prognostic estimate of CC, although further studies will be required to validate these findings.
Highlights
Colon cancer (CC) is the third most common cancer in both genders worldwide and the second cause of cancer-related death in western countries, only overcome by lung cancer [1, 2]
This study is the first approach on the prognostic significance of 14F7 Mab immunoreactivity in patients with colon adenocarcinoma and this assessment might be used in the prognostic estimate of CC, further studies will be required to validate these findings
We reported that higher 14F7 Mab immunostaining was significantly associated with impaired overall survival (OS) and disease-free survival (DFS), suggesting its potential use in the prognostic estimate of colon adenocarcinoma
Summary
Colon cancer (CC) is the third most common cancer in both genders worldwide and the second cause of cancer-related death in western countries, only overcome by lung cancer [1, 2]. In Cuba, CC is one of the most frequent tumors and the third cause of death by cancer in both men and women [3]. Despite the significant advances in the treatment and knowledge of the colon tumor biology over the last decade, the 5-year survival after surgery varies from 90% to 10%, depending on stage and progression of disease [2, 4]. It is important to increase our understanding of the molecular changes leading to development, spread, and metastasis and to identify potential prognostic and predictive markers for the disease. TNM (tumor-node metastasis) staging, based on the American Joint Committee on Cancer (AJCC) and the International Union against Cancer (UICC) classifications, has been the most important prognostic marker in CC [5]
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