Abstract
Objective: To explore the prognostic value of the expression of genes encoding structural maintenance of chromosomes (SMCs) in human sarcoma.Results: We found that the levels of SMC1A, SMC2, SMC3, SMC4, SMC5 and SMC6 mRNA were all higher in most tumors compared to normal tissues, and especially in sarcoma. According to the Cancer Cell Line Encyclopedia (CCLE), SMC1A, SMC2, SMC3, SMC4, SMC5 and SMC6 are also highly expressed in sarcoma cell lines. Results of Gene Expression Profiling Interactive Analysis (GEPIA) indicated that high expression of SMC1A was significantly related to poor overall survival (OS) (p<0.05) and disease-free survival (DFS) in sarcoma (p<0.05). Additionally, strong expression of SMC2 was significantly related to poor OS in sarcoma (p<0.05). In contrast, SMC3, SMC4, SMC5, and SMC6 expression had no significant impact on OS or DFS in sarcoma.Conclusions: Expression of SMC family members is significantly different in sarcoma relative to normal tissues, and SMC1A and SMC2 may be useful as prognostic biomarkers.Methods: We performed a detailed comparison of cancer and normal tissues regarding the expression levels of mRNA for SMC family members in various cancers including sarcoma through ONCOMINE and GEPIA (Gene Expression Profile Interactive Analysis) databases.
Highlights
Sarcomas constitute a group of malignant tumors that can differentiate into many different tissue lineages including fat, bone, fiber and muscle
SMC1A mRNA was significantly upregulated in sarcoma patients
Only the overexpression of SMC1A and SMC2 was related to the overall survival (OS) of sarcoma patients, whereas SMC3, SMC4, SMC5 and SMC6 had no significant impact on prognosis
Summary
Sarcomas constitute a group of malignant tumors that can differentiate into many different tissue lineages including fat, bone, fiber and muscle. In the United States, sarcomas account for 1% of newly diagnosed tumors and tumor-related deaths. These tumors were historically categorized as bone or soft tissue sarcomas, but more recent molecular classification divides them into genetically complex or genetically simple [1]. The hinge regions of two SMC proteins interact to mediate dimerization and take on a V-shaped molecular conformation. This family includes 6 proteins designated SMC1-6, of which the SMC1-SMC3 dimer forms the core of the cohesion protein complex and mediates the adhesion of sister chromatids. The start sequence of SMC5-SMC6 is slightly different from SMC1-SMC3, forming a third complex, which mainly plays a role in DNA replication and checkpoint response [3]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
