Prognostic Relevance of Pre- and Postoperative Arterial Blood Lactate Measurements, Procalcitonin and pH as Predictors of Outcomes in Secondary Peritonitis

Abstract

Secondary peritonitis is the most common form that follows an intra-peritoneal source usually from perforation of hollow viscera. Acute generalized peritonitis due to underlying hollow viscous perforation is a critical & life-threatening condition. It is a common surgical emergency in most of the general surgical units across the world. It is often associated with significant morbidity and mortality. In the present study Perforation peritonitis is associated with 12.8% mortality. Initial lactate, postoperative (24 hours) lactate is significant variables for mortality with critical values up to 3.78 mmol/L and 3.67 mmol/L respectively. Initial lactate, postoperative (24 hours) lactate values up to 2.29 mmol/L and 1.45 mmol/L respectively were reported in case of survivors. The lactate value of more than 2.5 mmol/L ascertained to have 64 % mortality. Initial pH, postoperative (24 hours) pH are significant variables for mortality with critical value of 7.16 and 7.17 respectively. Initial pH, postoperative (24 hours) pH value of 7.36 and 7.38 respectively were reported in case of survivors. Procalcitonin values of more than 2.58 ng/ml (normal range 0.01-0.05 ng/ml) ascertained to have 56.25 % mortality.