Abstract
Wick et al.1 determined that the interaction of molecular markers (methylguanine methyltransferase [ MGMT ], isocitrate dehydrogenase 1 [ IDH1 ], and loss of chromosomes 1p and 19q) in anaplastic gliomas (AG) was a hypothesis-generating analysis. This is because examination of interactive biomarkers was never prespecified as an endpoint in the NOA-04 trial.2 Biomarker determination segregates AG into 2 categories based on presence or absence of 1p19q codeletion.3 MGMT methylation or IDH1 mutation does not modify the prognostic …
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