Prognostic Nomogram of Prognosis-Related Genes and Clinicopathological Characteristics to Predict the 5-Year Survival Rate of Colon Cancer Patients.

Chao Huang,Jiefeng Zhao,Zhengming Zhu

doi:10.3389/fsurg.2021.681721

Abstract

Background: The Cancer Genome Atlas (TCGA) has established a genome-wide gene expression profile, increasing our understanding of the impact of tumor heredity on clinical outcomes. The aim of this study was to construct a nomogram using data from the TCGA regarding prognosis-related genes and clinicopathological characteristics to predict the 5-years survival rate of colon cancer (CC) patients.Methods: Kaplan–Meier and Cox regression analyses were used to identify genes associated with the 5-years survival rate of CC patients. Cox regression was used to analyze the relationship between the clinicopathological features and prognostic genes and overall survival rates in patients with CC and to identify independent risk factors for the prognosis of CC patients. A nomogram for predicting the 5-years survival rate of CC patients was constructed by R software.Results: A total of eight genes (KCNJ14, CILP2, ATP6V1G2, GABRD, RIMKLB, SIX2, PLEKHA8P1, and MPP2) related to the 5-years survival of rate CC patients were identified. Age, stage, and PLEKHA8P1 were independent risk factors for the 5-years survival rate in patients with CC. The accuracy, sensitivity and specificity of the nomogram model constructed by age, TNM staging, and PLEKHA8P1 for predicting the 5-years survival of rate CC patients were 83.3, 83.97, and 85.79%, respectively.Conclusion: The nomogram can correctly predict the 5-year survival rate of patients with CC, thus aiding the individualized decision-making process for patients with CC.

Highlights

Colon cancer (CC) ranks third in incidence and second in mortality rates [1]
The univariate analysis showed that the factors related to the overall survival rate of patients with CC were as follows: age (P = 0.010), stage (P < 0.001), T classification (P < 0.001), M classification (P < 0.001), N classification (P < 0.001), KCNJ14 (P < 0.001), CILP2 (P = 0.014), ATP6V1G2 (P < 0.001), GABRD (P = 0.005), TABLE 3 | Univariate analysis and multivariate analysis of the correlation of prognostic-related genes with overall survival among patients with colon cancer
The area under the curve (AUC), sensitivity and specificity of age combined with TNM staging for assessing the 5-years survival rate of CC patients were 0.735, 70.21, and 73.06%, respectively (Figure 4). These results indicated that age combined with TNM staging and PLEKHA8P1 were most accurate for evaluating the 5-years survival rate of CC patients

Summary

Introduction

Colon cancer (CC) ranks third in incidence and second in mortality rates [1]. The 5-years survival rates of patients with stage I, II, and III CC are ∼93, 80, and 60%, respectively [6]. The American Joint Committee on Cancer (AJCC) TNM staging system is widely used to assess the prognosis of patients with CC [5]. The prognosis of patients with CC at the same stage varies widely, and the accuracy of Prognostic Nomogram of Colon Cancer. The Cancer Genome Atlas (TCGA) has established a genome-wide gene expression profile, increasing our understanding of the impact of tumor heredity on clinical outcomes. The aim of this study was to construct a nomogram using data from the TCGA regarding prognosis-related genes and clinicopathological characteristics to predict the 5-years survival rate of colon cancer (CC) patients

Objectives

Methods

Results

Conclusion