Abstract
The association of pathobiochemical liquor markers with relapses and progression of multiple sclerosis in 60 patients with remitting-relapsing multiple sclerosis (RRMS) were studied. It is found that risk of MS relapse in the nearest three years is increased when the level of tumor necrosis factor alpha and matrix metalloproteinase 2 in cerebrospinal fluid is higher than median level. The risk of rapid progression of neurological deficit increases when the liquor level of soluble plateletendothelial adhesion molecule 1 (sPECAM-1), soluble adhesion molecules vascular endothelium type 1 (sVCAM-1) and matrix metalloproteinase 2 (MMP-2) exceeds the median level.
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