Abstract
Predicting the prognosis of gallbladder carcinoma (GBC) has always been important for improving survival. The objective of this study was to determine the risk factors of survival for patients with GBC after surgery and to develop predictive nomograms for overall survival (OS) and cancer-specific survival (CSS) using a large population-based cohort. We identified 2,762 patients with primary resectable GBC in the Surveillance, Epidemiology, and End Results (SEER) database for the period of 2004 to 2014 and another 152 patients with GBC after surgery from Sun Yat-sen University Cancer Center (SYSUCC) for the period of 1997 to 2017. The 1-, 2-, and 3-year cancer-specific mortalities were 37.2, 52.9, and 59.9%, while the competing mortalities were 5.8, 7.8, and 9.0%, respectively. Nomograms were developed to estimate OS and CSS, and these were validated by concordance indexes (C-indexes) and evaluated using receiver operating characteristic (ROC) curves. The C-indexes of the nomograms for OS and CSS prediction were 0.704 and 0.732, respectively. In addition, compared with the 8th Tumor-Node-Metastasis staging system, the newly established nomograms displayed higher areas under the ROC curves for OS and PFS prediction. The nomograms are well-validated and could thus aid individual clinical practice.
Highlights
Biliary tract cancers are relatively rare tumors globally; these diseases often carry a poor prognosis [1, 2]
Based on the data contained in the Surveillance, Epidemiology, and End Results (SEER) database, the present study aimed to evaluate the competing risks and to develop nomograms to investigate overall survival (OS) and cancer-specific survival (CSS) in patients with Gallbladder carcinoma (GBC) after surgery
A total of 1,760 deaths were observed during the follow-up period of 11 months, of which 1,502 were cancer-specific deaths and 258 deaths were from other causes
Summary
Biliary tract cancers are relatively rare tumors globally; these diseases often carry a poor prognosis [1, 2]. Gallbladder carcinoma (GBC), which is the most common biliary tract cancer, is traditionally regarded as a highly lethal disease with a 5-year survival rate of
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