Abstract
The pyometra is a disease that affects middle age and elderly female dogs during diestrus. Hormonal, microbiological, biochemical and hematological aspects are well described. However, few studies have evaluated the role of each in the prognosis of canine pyometra. The aim of this study was to identify markers associated with clinical worsening of dogs with pyometra. We prospectively evaluated 80 dogs with pyometra treated surgically. Group 1 consisted of dogs that were discharged within 48 hours after surgery and Group 2 consisted of those who required prolonged hospitalization or died. The findings of hematological, biochemical and blood lactate levels were compared between groups and variables such as bacterial multidrug resistance, systemic inflammatory response syndrome (SIRS), hyperlactatemia and increased creatinine were analyzed through the dispersion of frequencies between groups. Among the variables studied, the presence of SIRS and elevated serum creatinine >2.5mg/mL were effective in predicting the worsening of the disease and can be used as prognostic markers of canine pyometra.
Highlights
Pyometra is a disease that usually occurs during diestrus in intact adult females
The findings of hematological, biochemical and blood lactate levels were compared between groups and variables such as bacterial multidrug resistance, systemic inflammatory response syndrome (SIRS), hyperlactatemia and increased creatinine were analyzed through the dispersion of frequencies between groups
Of the 66 cases classified as SIRS positive, 21 (31.8%) had two of the four criteria, 28 (42.4%) were positive for three of the four criteria, and 17 (25.8%) were positive for all four criteria for SIRS diagnosis
Summary
Pyometra is a disease that usually occurs during diestrus in intact adult females. It is characterised by an inflammatory exudate and uterine bacterial colonisation associated with cystic endometrial hyperplasia (CEH) (Johnston et al, 2001).The haematological and biochemical abnormalities commonly found during the course of the disease are leukocytosis with neutrophilia, hyperglobulinaemia and azotaemia. Pyometra is a disease that usually occurs during diestrus in intact adult females. It is characterised by an inflammatory exudate and uterine bacterial colonisation associated with cystic endometrial hyperplasia (CEH) (Johnston et al, 2001). The haematological and biochemical abnormalities commonly found during the course of the disease are leukocytosis with neutrophilia, hyperglobulinaemia and azotaemia. Sant’Anna et al. Systemic inflammatory response syndrome (SIRS) is a clinical manifestation of the organism in response to an initial stimulus severe enough to produce a systemic release of inflammatory mediators. Sepsis is a disease manifested by SIRS of infectious origin (Purvis and Kirby, 1994)
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