Abstract
Background: Lung squamous cell carcinoma (LUSC) has been a highly malignant tumor with very poor prognosis. It is confirmed that pyroptosis refers to the deaths of cells in a programmed and inflammatory manner. Nevertheless, the correlation between expression of genes related with pyroptosis and their prognosis remains uncertain in LUSC. Methods: Utilization of The Cancer Genome Atlas (TCGA) cohort has been done for evaluating the prognostics of pyroptosis-related genes for survival and constructing a signature with multiple genes. The least absolute shrinkage and selection operator (LASSO) Cox regression was performed for establishing such pyroptosis-related gene signature. Results: Eventually, identification of 28 genes in relation to pyroptosis was made in LUSC and healthy lung tissues. Upon the basis of these differentially-expressed genes (DEGs), the patients of LUSC can be divided into two subtypes. Nine gene signatures were established using LASSO. The surviving rate for low-risk group was apparently greater in contrast with the high-risk group (p < .001). According to our finding, risk score worked as an independent predictive factor of OS among LUSC sufferers in combination with clinical characteristics. In line with Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses, the enrichment of immunity-related genes and decreasing immunity status among the high-risk group. Conclusion: Genes in relation with pyroptosis played an essential role in tumor immunity, which is capable of predicting the prognosis for LUSCs.
Highlights
Pulmonary carcinoma, the most serious malignant tumor, has been emphasized as a predominant reason for carcinoma death occurring in both developed and developing nations in the world (Mattiuzzi and Lippi, 2020)
In order to evaluate the prognosis of pyroptosis-associated genes, utilization of Cox regression analyses was further done for evaluating the correlation between surviving state and each gene in the The Cancer Genome Atlas (TCGA) cohort
Numerous studies have been conducted on Lung squamous cell carcinoma (LUSC), but this cancer is associated with poorer clinical outcomes compared with lung adenocarcinoma (Hirsch et al, 2017)
Summary
The most serious malignant tumor, has been emphasized as a predominant reason for carcinoma death occurring in both developed and developing nations in the world (Mattiuzzi and Lippi, 2020). Despite radiation and targeted therapies, the survival from lung cancer has not clearly improved, the overall 5 years surviving rate remains under 20% (Siegel et al, 2018). Such phenomenon has seriously impacted human health, and lung cancer has attracted the public attention to health. As a common histologic subtype of lung carcinoma, LUSC is often not promptly diagnosed clinically and has inherent resistance to radiation and chemotherapy due to its early symptoms is not typical. Lung squamous cell carcinoma (LUSC) has been a highly malignant tumor with very poor prognosis. The correlation between expression of genes related with pyroptosis and their prognosis remains uncertain in LUSC
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