Abstract
A total of 472 epilepsy patients with a 4-year remission period were divided into 10-year age groups according to age of onset. The relapse patterns during at least 3 years of follow-up were classified as early relapse (ER), late relapse (LR), and seizure-free (SF). The remission probability and multiplicity of prognostic factors were evaluated using univariate and multivariate multinomial logistic analyses. The weighted risk score based on odd ratios (ORs) was used for comparisons of the relative risk of relapse between groups. The group with onset in their 20s had the lowest remission probability among the groups. The risks of relapse in the LR patients and the relative weighted risk score of ER patients in the group with onset in their 20s were 3.11 and 19.44, respectively, which was the highest risk among the age groups. Patients without remission within 1 year had the highest relapse risk, with an OR of 7.18 in ER patients. The OR of relapse in patients with >10 generalized tonic–clonic (GTC) seizures was the second most important prognostic factor in LR patients. The distinct risk and corresponding prognostic factors in LR and ER patients reflected inherent differences between these relapse patterns.
Highlights
Age at onset of epilepsy and symptom duration have been consistently reported as important prognostic factors
There was a significant relationship between age at onset of epilepsy and symptom duration in all subjects (Figure 2)
Symptom duration is a well-known prognostic factor that is inevitably related to the age at onset of epilepsy
Summary
Age at onset of epilepsy and symptom duration have been consistently reported as important prognostic factors. The age at onset of epilepsy and symptom duration are closely correlated with each other. Localization-related seizures, relevant lesions on a brain scan, achievement of seizure control within 1 year, and the total number of generalized tonic–clonic (GTC) or generalized seizures have been reported as important prognostic factors, in addition to conventional prognostic factors such as antecedents of epilepsy. Incomplete achievement of remission or relapse back to the pretreatment condition result in the prolongation of the total symptom duration. These results suggested the importance of achieving early control of seizures. Almost all prognostic factors are related to symptom duration
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
