Abstract
The in vitro culture studies have revealed that the infinite proliferation of leukemic cells in acute myelocytic leukemia (AML) is supported by leukemic blast progenitors with self-renewal capacity. The self-renewal of blast progenitors is assessed by either secondary blast colony-formation in methylcellulose culture or clonogenic cell recovery in suspension culture. The patients whose leukemic blast progenitors had high self-renewal ability were more difficult in achieving complete remission and survived for shorter term than those with leukemic blast progenitors of low self-renewal capacity. Namely, the self-renewal capacity of leukemic blast progenitors was highly predictive of not only remission induction outcome but also survival duration of AML patients. Among several antileukemic agents tested, only a few drugs such as cytosine arabinoside were effective against blast self-renewal. To cure AML, a therapy that aims to eradicate self-renewing leukemic blast progenitors should be developed.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
