Abstract
Adenocarcinoma (ADC) is the most common histological type of lung cancer and its proportion is rising, especially in Asian non-smoking women. Recent studies suggest miR-25 may have diverse effects on the pathogenesis of different types of cancer. However, the role of miR-25 in lung cancer is still unknown. The aim of this study was to investigate the potential clinical value of miR-25 in non-smoking women with lung ADC. Quantitative RT-PCR was performed to evaluate the expression of miR-25 in 100 lung ADC tumor tissues and matched plasma samples and Pearson correlation tests were used to analyze the relationship between values. Associations of miR-25 expression with clinicopathological features were determined using the Student's t-test. To determine prognostic value, overall survival (OS) was evaluated using the Kaplan-Meier method. Univariate and multivariate analyses were performed using the Cox proportional hazard model. Expression of miR-25 in tissue was found to be associated with lymph node metastasis (P=0.021) and disease stage (P=0.012). Moreover, high miR-25 expression was also associated with poorer overall survival of women with lung ADC (P=0.008). Tissue miR-25 expression may be associated with tumor progression and have prognostic implications in female lung ADC patients.
Highlights
Lung cancer is the leading cause of cancer-associated death worldwide, and non-small cell lung cancer (NSCLC) accounts for approximately 80% of all lung cancers (Siegel et al, 2012)
Patients and Methods: Quantitative reverse transcription (RT)-PCR was performed to evaluate the expression of miR-25 in 100 lung ADC tumor tissues and matched plasma samples and Pearson correlation tests were used to analyze the relationship between values
Non-smoking lung adenocarcinoma (ADC) has been prominently increasing worldwide, and the incidence is high in Asian women in which ADC is the most common histological type (Toh et al, 2006; Toh and Lim 2007; Wakelee et al, 2007)
Summary
Lung cancer is the leading cause of cancer-associated death worldwide, and non-small cell lung cancer (NSCLC) accounts for approximately 80% of all lung cancers (Siegel et al, 2012). Adenocarcinoma (ADC) is the most common histological type of lung cancer and its proportion is rising, especially in Asian non-smoking women. The aim of this study was to investigate the potential clinical value of miR-25 in non-smoking women with lung ADC. Patients and Methods: Quantitative RT-PCR was performed to evaluate the expression of miR-25 in 100 lung ADC tumor tissues and matched plasma samples and Pearson correlation tests were used to analyze the relationship between values. High miR-25 expression was associated with poorer overall survival of women with lung ADC (P=0.008). Conclusion: Tissue miR-25 expression may be associated with tumor progression and have prognostic implications in female lung ADC patients
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