Prognostic impact of the combination of the neutrophil-to-lymphocyte ratio and serum CA19-9 in patients with pancreas head cancer

Abstract

Introduction: This study aimed to evaluate the clinical value of the combination of a traditional prognostic factor with a systemic inflammation-based prognostic factor in patients undergoing curative resection for pancreas head cancer diagnosed as pancreatic ductal adenocarcinoma (PDAC). Method: From January 2005 to December 2015, 198 patients were enrolled. Various clinicopathologic factors potentially associated with survival and recurrence were evaluated in this study. Result: The selected cut-off values for the test prognostic factors with sufficient sensitivity and specificity were 2.8 for the NLR and 70 U/mL for serum CA19-9. Kaplan-Meier survival analysis demonstrated that the 5-year survival rate in patients with a high NLR and CA19-9 was 21.8% compared with 79.8% for patients with a low NLR and CA19-9. The 5-year disease free-survival rate in patients with a high NLR and CA19-9 was 0% compared with 33.9% for patients with a low NLR and CA19-9. Patients with high NLRs and high CA19-9 were more likely to have an early recurrence and multiple relapse patterns. Conclusion: Preoperative NLR and serum CA19-9 offer significant prognostic information for survival following curative resection of pancreas head cancer diagnosed as PDAC.