Abstract
Intrahepatic distant recurrence, after successful radiofrequency ablation for hepatocellularcarcinoma, is related to many factors. Underlying liver fibrosis/cirrhosis severity thought to beone of these contributors. FIB-4 index is a non-invasive marker which reflects the severity ofliver fibrosis. The aim of this study was to evaluate the prognostic value of FIB-4 index afterradiofrequency ablation for hepatocellular carcinoma with curative intent. This retrospectivestudy included 121 HCV related hepatocellular carcinoma patients with Child class A who underwentradiofrequency ablation between 1/2010 & 12/2014. The study assessed the overallsurvival and denovo intrahepatic distant recurrence using pretreatment FIB-4 index.The result showed that pretreatment FIB-4 index of ≤3.25 patients had significant better freeintrahepatic distant recurrence and overall survival rates after radiofrequency ablation when comparedto those with pretreatment FIB-4 index of > 3.25, even in subsets of patients with Childscore 5, single lesion or lesions< 3cm. Also, FIB-4 index was useful prognostic predictor of intrahepaticdistant recurrence and overall survival after radiofrequency ablation in Child class Apatients in uni and multivraite analysis.
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