Prognostic impact of MYH9 expression on patients with acute myeloid leukemia.

Mengxia Yu,Zhijuan Zhu,Dongmei Wang,Ting Zhang,Chao Hu,Yungui Wang,Feifei Chen,Hanzhang Pan,Jie Jin,Jian Chen,Jiansong Huang,Qiuling Ma,Zhixin Ma,Yile Zhou,Xia Li,Chenying Li,Xiufeng Yin,Jinghan Wang

doi:10.18632/oncotarget.10613

Abstract

MYH9 expression has previously been demonstrated as an independent predictor of clinical outcome in solid tumors. However, the prognostic relevance of MYH9 expression in acute myeloid leukemia is still unclear. Here, we found high MYH9 expressers were seen more frequently in females and more frequently in M4 morphology. We also found high MYH9 expressers had lower percentage of bone marrow blasts. In addition, overexpression of MYH9 was associated with an inferior overall survival. Notably, distinct microRNA signatures were seen in high MYH9 expressers. These results were also validated in an independent cohort of AML patients using the published data. In conclusion, gene of MYH9 expression might serve as a reliable predictor for overall survival in AML patients.

Highlights

Acute myeloid leukemia (AML) is a heterogeneous group of hematologic malignancies characterized by a wide spectrum of prognostically relevant cytogenetic aberrations, oncogenes of mutations and/or abnormal expressions
In our phase 3 clinical trial, we found favorable cytogenetics can serve as a survival predictor for patients with AML when treated with homoharringtonine (HHT)-based chemotherapy [2]
We reported that high MYH9 expression associated with shorter overall survival in AML

Summary

Introduction

Acute myeloid leukemia (AML) is a heterogeneous group of hematologic malignancies characterized by a wide spectrum of prognostically relevant cytogenetic aberrations, oncogenes of mutations and/or abnormal expressions. We found myosin-9 was one of the critical targets in AML cell lines. Up-regulated myosin-9 may increase the sensitivity of the leukemia cells to the cytotoxicity of HHT in vitro. Taken together, these results indicated over-expressed MYH9 might associate with favorable prognosis in leukemia. These results indicated over-expressed MYH9 might associate with favorable prognosis in leukemia These results are from experiments in vitro, and may not always be in line with the results in vivo. It is urgent for us to explore the prognostic value of MYH9 expression in AML

Methods

Results

Conclusion