Prognostic Impact of Early ST-Segment Resolution and Biochemical Markers in Patients With ST-Elevation Myocardial Infarction

Abstract

Refer to the page 372-378 Considerable variability exists for the reported mortality risk among patients with ST-elevation myocardial infarction (STEMI) and who are treated with primary percutaneous coronary intervention (PCI). The diversity in the clinical out comes for these patients challenges the physician at each step: risk stratification, planning the treatment and monitoring the response to PCI. In this regard, the current guidelines for the treatment of patients with acute coronary syndrome (ACS) recommend risk stratification using a variety of clinical vari ables. Clinical variables such as biomarkers, electrocardiography (ECG), and the imaging modalities have been studied for whether these variables may improve the risk assessment and clinical care. The standard 12-lead ECG has been used as the single most important diagnostic tool for the evaluation of ACS. Measurement via ECG is very useful and informative for determining the quality of reperfusion in patients with acute STEMI. The degree of ST segment deviation also confers prognostic information. 1) Since it was first documented in 1971 in an animal study that the magnitude of ST segment elevation was well correlated well with depressed myocardial creatine kinase activity as well as myocardial necrosis, 2) the degree of ST segment elevation has been used as an