Abstract
BackgroundTo identify prognostic factors for grade 3 radiation dermatitis following passive-scattering proton therapy for breast cancer.MethodsThis retrospective study included data on 23 (11 post-mastectomy and 12 post-lumpectomy) breast cancer patients who underwent proton therapy with the passive scattering technique in our institute from 2012 to 2016. Each patient received 50–50.4 cobalt Gy equivalent (CGE) at 1.8 or 2 CGE per daily fraction. Logistic regression analysis was performed to identify prognostic factors for grade 3 skin toxicity. Receiver operating characteristic (ROC) curve analysis and the area under the curve (AUC) were used to evaluate the performance of the models.Results43% of the studied patients developed grade 3 radiation dermatitis. The dose-volume histogram (DVH) parameters of V52.5CGE and D10cm3 to skin5mm were correlated with grade 3 radiation dermatitis in both univariate and multivariate logistic regression analyses. Univariate logistic regression analysis suggested that D10cm3 to skin5mm (AUC = 0.69) and V52.5CGE to skin5mm (AUC = 0.70) were prognostic for grade 3 skin toxicity. The models using the combination of D10cm3 to skin5mm or V52.5CGE to skin5mm with breast volume marginally increased the AUC to 0.72 and 0.73, respectively. Models using the combination of D10cm3 to skin5mm or V52.5CGE to skin5mm with history of smoking increased the AUC to 0.75 and 0.83, respectively.ConclusionIn the current study, we identified prognostic factors for grade 3 radiation dermatitis in patients treated with passive-scattering proton therapy for breast cancer. This study provides promising tool for identifying high risk patients for whom treatment plan adjustment could be done to reduce the risk of radiation-induced grade 3 skin toxicity.
Highlights
To identify prognostic factors for grade 3 radiation dermatitis following passive-scattering proton therapy for breast cancer
The purpose of this study is to identify prognostic factors of developing grade 3 radiation dermatitis following passive-scattering proton therapy, so that for those patients who are at high risk of severe skin toxicity, the treatment plans can be adjusted to reduce the risk
We retrospectively evaluated 23 (11 postmastectomy and 12 post-lumpectomy) patients with breast cancer who were treated with passive-scattering proton technique in our institute from 2012 to 2016
Summary
To identify prognostic factors for grade 3 radiation dermatitis following passive-scattering proton therapy for breast cancer. Compared with conventional photon-based radiation therapy, proton therapy can deliver radiation therapy to breast cancer targets with. Radiation dermatitis is the predominant acute side effect of radiotherapy for breast cancer. Radiation dermatitis can progress from erythema to dry desquamation to moist desquamation and even to ulceration [9], after which permanent skin. Severe acute reactions can lead to interruption or premature discontinuation of radiation therapy and potentially negatively influencing cancer control and prognosis. Numerous trials aiming to prevent acute radiation adverse effects to skin using creams, hygiene or semi-permeable dressing have been reported, but their efficacy in prevention of skin reactions has not been consistently demonstrated across studies [10,11,12,13]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
