Prognostic Factors Of In-Hospital Mortality In Adult Patients With Aluminum Phosphide (ALP) Poisoning In Southern Iran (2014-2018):

Abstract

Introduction: The suicide with aluminum phosphide (ALP) which is known as rice tablet has increased significantly. This study aimed to investigate the epidemiology of ALP poisoning and determining the in-hospital mortality prognostic factors in adult people referring due to ALP poisoning to one of the main poisoning center in southern Iran. Methods: This retrospective cross-sectional study (21/March/2014 to 21/March/2018) was conducted on all adult patients (> 16 years) with ALP poisoning, who were referred to Ali-Asghar Hospital (affiliated by Shiraz University of Medical Sciences). All data were extracted from the patients' medical files. The patients were categorized as two groups of survived and non-survived. Univariate and multivariate logistic regression analysis were applied to determine prognostic factors for in-hospital mortality, and odds ratios (ORs) were reported. Results: Totally, 97 patients were enrolled. The mean±SD of age was 29.3±12.2. Both groups were the same in most of demographic and poisoning characteristics. Nausea (62.9%) and vomiting (49.5%) were the most symptoms at the time of admission. Castor oil (66%), N-Acetyl Cysteine (56.7%), and magnesium sulfate (52.6%) were the most frequent treatment in these patients. The multivariate analysis showed that age (OR=1.12, 95%CI; 1.03-1.22), be illiterate (OR=39.95, 95%CI=0.85-11887.59), temperature (OR=0.02, 95%CI=0.01-0.48), resistant acidosis (OR=77.10, 95%CI; 5.05-1176.86), and taking sodium bicarbonate (OR=12.35, 95%CI; 1.25-122.10) were the prognostic factors of in-hospital mortality. Conclusion: The in-hospital mortality rate in patients with ALP poisoning was 29.9%. Age, be illiterate, body temperature, resistant acidosis, and taking sodium bicarbonate were the prognostic factors of in-hospital mortality in these patients.