Abstract
Methods An extensive data search was conducted from all leading databases including PubMed, Google Scholar, Embase, and Cochrane. Fifteen studies were selected according to the PRISMA model of data selected to conduct this systemic review meta-analysis. Results Total 4444 patients were evaluated among fifteen selected studies. A number of lymph nodes involved (n = 3965), level of lymph nodes (n = 3422), and complete tumor resection (n = 3255) were the most reported prognostic factors. Conclusion This study exhibits the overall significance of all prognostic factors of NSCLC IIIAN2 pathology for better patient management. However, other management strategies also play a significant contribution to achieving a better survival rate and less recurrence possibility.
Highlights
Cancer is one of the leading causes of all medical mortalities and one of the greatest medical challenges to date [1, 2]
Almost 30% of Non-small-cell lung cancer (NSCLC) reported cases already have an advanced form of pathogenesis, at the time of presentation
Stage III further classifies into IIIA and IIIB, and about 10% of the advanced cases of NSCLC stage III belong to IIIA-N2
Summary
Cancer is one of the leading causes of all medical mortalities and one of the greatest medical challenges to date [1, 2]. Human lungs are the most reported target sites for cancer development with a comparatively poor survival rate [1]. Non-small-cell lung cancer (NSCLC), stage III, belongs to the one for the tough management domain because of its heterogeneous nature. Almost 30% of NSCLC reported cases already have an advanced form of pathogenesis, at the time of presentation. Stage III further classifies into IIIA and IIIB, and about 10% of the advanced cases of NSCLC stage III belong to IIIA-N2. This subclassification is based on the metastasis of mediastinal lymph nodes [3,4,5]
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