Prognostic factors of colorectal carcinoma in the elderly after radical surgery

Abstract

To evaluate the prognostic factors of colorectal carcinoma in the elderly aged over 70 after radical surgery. 263 colorectal carcinoma patients aged 74.9, 147 males and 115 females, underwent radical surgery, including right hemicolectomy (n=48), left hemicolectomy (n=11), transverse colectomy (n=8), sigmoid resection (n=27), low anterior resection (n=103), abdominoperineal resection (n=58), and Hartmann's operation (n=7). Survival analysis was conducted using Kaplan-Meier method, and multivariate analysis was conducted with Cox regression to analyze the prognostic factors. The post-operative complication rate was 14. 4%. The 30-day mortality was 1.1%. The overall 5-year survival rate was 70.5%, and the 5-year survival rates of the patients with ASA grades I, II, and III were 84.8%, 71.8%, and 61.9% respectively. Univariate analysis showed that the predictors of survival were age, co-morbidity, ASA score, postoperative complication, preoperative serum albumin concentration, preoperative hemoglobin level, gross tumor configuration, tumor stage, neoplastic intestinal obstruction, and lymph node metastasis. Multivariate analysis showed that patient sex, complication, operative complication, gross tumor configuration, depth of infiltration, lymph node metastasis, and tumor staging were independent influencing factors od prognosis. The prognosis of colorectal carcinoma in the elderly after radical surgery is good. The prognostic factors include age, postoperative complication, and pre-operative serum albumin concentration, and gross tumor configuration, depth of tumor invasion, lymph node metastasis, and tumor stage.