Abstract
The number of the bile ducts in the portal canal/measured surface area of the portal canal (BDP ratio) indicates prognosis in biliary atresia (BA), as does an elevated cytokeratin 7 positivity percentage (PCK7). We compared these two markers. We reviewed 32 BA cases undergoing Kasai operation from 1976 to 2016 with >5 portal canals in biopsy samples. Group I required liver transplantation or died within a year of operation (n=8). Group II survived with their native liver (n=24). We determined the BDP ratio (102/mm2) and PCK7 (%), subdividing patients into three groups by their age at operation: Group A ≤60days (n=6, 1 Group I), 60< Group B ≤90days (n=16, 5 Group I), Group C >90days (n=10, 2 Group I). PCK7 (%) was 2.71±1.87 in Group I and 4.25±2.56 in Group II (p=0.13). BDP ratio (102/mm2) was 1.19±0.424 in Group I and 1.64±0.534 in Group II (p=0.04). Both markers were higher in Group C than in Group A or B (p<0.01). The BDP ratio is a better prognostic indicator than PCK7 in BA.
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