Prognostic factors in malignant ovarian germ cell tumors: The SEER experience 1978-2010.

Abstract

e15534 Background: In patients with malignant ovarian germ cell tumors (MOGCT) to evaluate the prognostic significance of age at diagnosis, extent of the disease (EOD), socioeconomic (SES) and sociodemographic status (civil status, residency) on cause specific survival (CSS). To explore the cumulative incidence of a second cancer in 10-year MOGCT survivors. Methods: 2541 patients with MOGCT, reported to the Surveillance, Epidemiology, and End Results program (1978 to 2010), were identified. The above mentioned prognostic factors were assessed separately for dysgerminoma and non-dysgerminoma, using Kaplan Meier estimates and Cox Hazards Models, providing 95% confidence intervals (95% CI). Results: Five-year CSS was 97.0% (95% CI, 95.8% to 98.2%), and 92.0% (95% CI, 90.6% to 93.4%), respectively for dysgerminoma, and non-dysgerminoma. Increasing age at diagnosis and presence of metastasis were significantly associated with cause specific mortality. Among non-dysgerminoma patients, decreasing SES (HR, 1.59; ...