Prognostic factors in an 85 patient series of digestive neuroendocrine tumours with surgery or endoscopic resection.

Abstract

Background: The aim of this study is to analyze prognostic factors for survival and recurrence in patients with diagnosis of digestive neuroendocrine tumours (DNT) and underwent a surgery and/or endoscopic resection Methods: Medical records of 85 patients with DNT were retrospectively reviewed since 1990- 2016. The variables studied were: age, sex, form of presentation, localization, metastasis, treatment, type of surgery and state of tumour, including WHO classification (2010). Results: From 85 patients, 51.8% were male, with a median age of 61 years (29-81). By location, the most frequent tumour was small bowel DNT (27.1%) and appendix (25.9%). Appendicular tumours presents in youngest patients (39 years; 8-78) vs colon (67years; 36-83) (p=0.004). Regarding the mode of presentation, it was sporadic (36.5%) and appendicitis (21.2%). Surgery was the most common treatment of primary tumour (73.5%) and endoscopic resection was enough in the 8.2%. There was synchronous metastasis in 37.6% (hepatic location 32.9%) and this presents association with location (small bowel and stomach; p<0.001). The 1, 3 and 5-years survival was 89.3%, 75% and 58.4%. Univariate and multivariate survival analysis showed that location, presentation clinic, WHO classification and presence of metastasis are independent predictor factors. Conclusion: In our experience, location, presentation clinic, WHO classification and presence of metastasis were an independent prognostic factors in DNT survival.