Abstract
Prognosis of acute myeloid leukemia (AML) patients depends on patient-related features, disease manifestations at the time of presentation, and intrinsic disease-related genetic features, such as cytogenetic abnormalities and driver mutations. Prognostic stratification also depends on the therapeutic strategy and on response to treatment, including measurable residual disease assessment. This chapter reviews the influence of prognostic factors measured at the diagnosis of AML, with an emphasis on disease-related factors. The role of measurable residual disease and how prognostic stratification affects treatment decisions are covered in other chapters.
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