Abstract
Background: In recent years, the survival rate of laryngeal carcinoma patients has been demonstrating a decreasing trend from (57.1% to 51.9%) we retrospectively analyze the various prognostic factors in patients with advanced laryngeal cancer. To explore the best options across the continuum of care for patients.Patients and Methods: A retrospective analytic study evaluating prognostic factors in 110 patients with advanced laryngeal carcinoma. Selected prognostic factors includes age, gender, smoking, tumor subsite, TNM classification, clinical staging, thyroid cartilage invasion, treatment modality, surgical margins, Preoperative tracheostomy, postoperative fistula, associated comorbidities (chronic diseases).Results: All patients were followed up for at least 36 months, the survival rates 1, 2 and 3 years after the treatment were 91.8%, 81% and 68.1% respectively. The disease-free progression rates were 89%, 81% and 71.8% respectively.Conclusion: The increase in Age, Trans-glottic tumors, Thyroid cartilage invasion and Stage-IV AJCC; had an independent effect on increasing the probability of mortality occurrence
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