Prognostic factors for visual outcome after intravitreal bevacizumab injection for pigment epithelial detachment in AMD

Abstract

AbstractPurpose To evaluate the prognostic factors for visual outcome after intravitreal bevacizumab injection in patients with pigment epithelial detachment (PED) in AMDMethods Thirty eyes in 30 patients with CNV and PED in AMD who had received intravitreal bevacizumab injections were retrospectively reviewed. Initial visual acuity, pigment epithelial detachment size, retinal or subretinal fluid resolution and CNV location were evaluated at 12 months.Results Initial visual acuity was not correlated with BCVA at 12 months (p=0.063). CNV at the edge of PED appears to respond more favorably at 12 months (p=0.033) than CNV within PED. Sub and intraretinal fluid initially resolved faster than the sub‐PED fluid (P = 0.041).The subretinal pigment epithelial fluid was highly resistant. Sub and intraretinal fluid response did not appear to be related to PED size. Visual acuity improvement was similar in both groups: large and minimal PED component.Conclusion The location of CNV and the retinal or subretinal fluid resolution were the main prognostic factors for visual outcome. Bevacizumab was very effective in reducing more of the sub‐ and intraretinal fluid than the PED fluid in AMD with CNV.