Abstract
ObjectivesMeningioma recurrence remains a significant issue. No study has described the relationship between the clinical features and prognosis of communicating meningioma that primarily originates from the olfactory groove. The aim of the study was to identify prognostic factors of communicating olfactory groove meningiomas that could be stratified according to their risk of recurrence.ResultsA Simpson grade one or two resection was achieved. Complications with cerebrospinal rhinorrhoea occurred in two patients: one required reoperation, and the other was managed successfully with external drainage of lumbar cistern. There were 5 known clinical recurrences within the median follow-up of more than 5 years. The median 5-year recurrence-free survival for patients was 88.4%. Factors such as gender, tumour size, T2 signal and the hyperostotic bone had no significant effect on recurrence-free survival. However, recurrence was activated by oedema range, hyperostosis, dural tail sign and tumor texture (p < 0.05). Interestingly, female patients with the disease were younger than males at diagnosis, and the difference was statistically significant (p = 0.013).ConclusionsBased on these features of communicating olfactory groove meningiomas, different strategies may be adopted for the follow-up and subsequent treatment. Due to the relatively uncommon incidence, more investigations into the clinical behaviour of this entity are crucial.Patients and MethodsA retrospective study of 43 patients harbouring olfactory groove meningiomas invading the ethmoid or nasal cavity was conducted at three medical centers from 2000 to 2010. The records were reviewed for clinical presentations, imaging studies, surgical observation, histological features and follow-up.
Highlights
Meningiomas are commonly considered to grow slowly, and cured by conventional surgery [1]
The clinical behaviour of meningiomas originating from olfactory groove has been documented, but very little is known regarding the prognostic factors of olfactory groove meningiomas (OGMs) with extension into the ethmoid sinuses or nasal cavity [3]
Follow-up procedures were put into effect in accordance with a standard clinical protocol that consisted of magnetic resonance imaging (MRI) performed 3 months after surgery in the first year and every one or two years thereafter
Summary
Meningiomas are commonly considered to grow slowly, and cured by conventional surgery [1]. The clinical behaviour of meningiomas originating from olfactory groove has been documented, but very little is known regarding the prognostic factors of olfactory groove meningiomas (OGMs) with extension into the ethmoid sinuses or nasal cavity [3]. The majority of the disease relapses occur among World Health Organization (WHO) grade I patients [4]. Failing to understand the clinical behaviour of these tumours can cause inadequate attention for treatment and follow-up. Based on this information, there is an urgent need to identifying reliable prognosis factors of communicating OGM to adopt different treatments and an efficient follow-up strategy for individual patients
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