Prognostic factors for cervical cancer patients stages IB-IVA treated by radiotherapy with or without chemotherapy

Abstract

The prognostic factors for cervical cancer has been associated with a poor treatment response and reduced survival rate. The objective of this study was to evaluate the prognostic factors for patients with cervical cancer. A total of 1,548 patients with cervical cancer stage IB-IVA, who had been treated by radiotherapy with or without chemotherapy between 1997 and 2001, were identified by the radiotherapy registry database at MaharajNakorn Chiang Mai Hospital, Thailand. The 5-year survival rate was calculated using the Kaplan-Maier method and compared with the Log rank test. The multivariate analysis of survival was performed with a Cox regression analysis. Prognostic factors for the overall 5–year survival rate were: advanced stage (Hazard ratio (HR) = 1.62), hemoglobin level ≤ 11 g/dl (HR = 1.16), pathology type adenocarcinoma (HR = 1.26), grade of pathology: moderately differentiated (HR = 1.34); poorly differentiated (HR = 1.43), smoking (HR = 1.25), performance status level < 60% (HR = 1.58), age > 50 years (HR = 1.43), treatment by radiotherapy together with chemotherapy (HR = 1.31) and overall treatment time frame of > 8 weeks (HR = 1.28). Most of the prognostic factors for the 5-year survival rate of these cervical cancer patients could not be controlled. However, red blood cell transfusion for bleeding or severe chronic anemia may be lifesaving for anemia patients. Moreover, similar to other studies, the overall treatment time was an important prognostic factor for cervical cancer.