Abstract
BackgroundThe purpose of this study was to review patient characteristics and evaluate the potential factors affecting prognosis in cases of brain metastasis (BM) from colorectal cancer (CRC).MethodsWe retrospectively reviewed 93 cases of BM from CRC in our hospital. Patient demographics, neurologic symptoms, and location and number of BMs were recorded. Factors analyzed included: age; sex; Karnofsky performance score; number of BMs; presence of extracranial metastases; dimensions; location of tumors; treatment modalities.ResultsThe overall 1- and 2-year survival rates were 27.7 and 9.9 %. On multivariate analysis, the number of BMs, extracranial metastases and the initial treatment modalities were found to be independent prognostic factors for overall survival. Patients treated with surgical resection followed by WBRT or SRS had an improved prognosis relative to those treated with surgery alone (P = 0.02 and P = 0.02, respectively). No significance difference in survival rate was found between patients treated with SRS alone or SRS plus WBRT (P = 0.11).ConclusionsSurgical resection of BMs from CRC in selected patients may help prolong survival. Additional radiotherapy following surgery is valuable in improving prognosis. Extracranial metastasis, multiple BM lesions and initial non operation can be considered as independent factors associated with poor prognosis.
Highlights
The purpose of this study was to review patient characteristics and evaluate the potential factors affecting prognosis in cases of brain metastasis (BM) from colorectal cancer (CRC)
50 % of CRC patients will die of metastatic disease [3]
CRC is the most common primary lesion among BMs originating from tumors in the gastrointestinal tract; a recent systematic review found that 79.9 % (2028/2538) of BMs originated from tumors in the gastrointestinal tract [8]
Summary
The purpose of this study was to review patient characteristics and evaluate the potential factors affecting prognosis in cases of brain metastasis (BM) from colorectal cancer (CRC). Colorectal cancer (CRC) is the second-leading cause of cancer-related deaths after lung cancer [1]. 50 % of CRC patients will die of metastatic disease [3]. In CRC cases, the incidence of brain metastasis (BM) is much lower than at other common metastatic sites such as the lung, liver, and peritoneal cavity; BM accounts for only 2–3 % of. The present study was conducted to analyze the clinical characteristics and outcomes of treatment modalities in patients with BM from CRC, to identify independent prognostic factors, and to provide information on related clinical experience of treatment. Gu et al BMC Cancer (2015) 15:902
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