Abstract
Objective: this study aimed to evaluate long-term survival and prognostic factors in patients with oral squamous cell carcinoma (OSCC) in an economically poor region of Brazil.Methods: the data were obtained from analysis of medical and mortality records of 210 patients with OSCC treated at an oncology hospital providing services to the Brazilian Unified National Health System in a State of northeastern Brazil between January 2006 and December 2008. Sociodemographic and clinical information, treatment performed, recurrence and evolution were collected. Survival curves were estimated by the Kaplan-Meier method and the log rank and Cox regression tests were used to compare the curves.Results: the median survival in the study period was 47.4 months (95% CI = 38.2 - 56.7). The overall survival rates at 5 and 10 years were 29% and 19.8%, respectivelly. Individuals over 60 years of age (HR = 1.70; 95% CI = 1.06 - 2.73), presence of regional metastasis (HR = 2.51; 95% CI = 1.55 - 4.08), presence of recurrence (HR = 3.18; 95% CI = 1.88 - 5.39) and no surgical treatment (HR = 2.10; 95% CI = 1.31 - 3.35) had a worse prognosis.Conclusions: advanced age, presence of regional metastasis, tumor recurrence and non-surgical treatment predict poorer survival in patients diagnosed with OSCC.
Highlights
Oral cavity cancers correspond to about 30% of all head and neck tumors, around 90% of those tumors are histologically squamous cell carcinomas (SCC) (1)
The present study aims to evaluate the survival of patients diagnosed with Oral squamous cell carcinomas (OSCC) and the associated prognostic factors, in a cancer reference center providing services to the Brazilian Unified National Health System in a State of northeastern Brazil
51.8% were in an advanced stage (IV), 42.9% with tumor size T4, 55.7% absence of lymph node metastasis (N0) and 92.9% absence of metastasis the distance (M0)
Summary
Oral cavity cancers correspond to about 30% of all head and neck tumors, around 90% of those tumors are histologically squamous cell carcinomas (SCC) (1). 15,000 new cases of oral SCC are expected in Brazil for each year of the 2020-2022 triennium (11,180 cases in men and 4,010 in women) (2). It corresponds to an estimated risk of 10.69 new cases per 100 thousand men and 3.71 for every 100 thousand women, occupying the fifth and the thirteenth position among the most frequent malignant tumors in men and women, respectively (2). Adjuvant radiotherapy and/or chemotherapy are usually indicated when there are pathological factors that increase the risk of tumor recurrence (3, 4)
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